Pancreatic GIST in a Patient with Limited Stage Small Cell LungCancer: A Case Report and Review of Published Cases

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and usually occurin the stomach and the small intestine. The pancreas is an extremely rare primary site for GISTs and there are 25 reported casesof pancreatic GIST with most being treated with surgical resection. We describe a 52-year-old African-American female who wasdiagnosed with limited stage small cell carcinoma in November 2009 and treated with concurrent cisplatin/etoposide chemotherapyand radiation. She subsequently achieved complete remission. Two years later she was diagnosed with localized pancreatic GIST byendoscopic ultrasonography guided fine needle aspiration. We treated her with a tyrosine kinase inhibitor (TKI) imatinib 400 mgoraldosedailyasshedeclinedsurgery.Herdiseaseisstablebasedoncomputedtomographyimagingscans40monthsafterdiagnosiswithout any metastasis. To the best of our knowledge, our case is the second case of localized pancreatic GIST treated with TKImonotherapy.