Author/Authors :
Pavlidis, Nicholas Department of Medical Oncology - University Hospital of Ioannina - Ioannina, Greece , Kollas, Aristomenes Department of Medical Oncology - University Hospital of Ioannina - Ioannina, Greece , Zarkavelis, George Department of Medical Oncology - University Hospital of Ioannina - Ioannina, Greece , Kafantari, Aikaterini Department of Medical Oncology - University Hospital of Ioannina - Ioannina, Greece , Goussia, Anna Department of Pathology - University Hospital of Ioannina - Ioannina, Greece , Batistatou, Anna Department of Pathology - University Hospital of Ioannina - Ioannina, Greece , Evangelou, Zoi Department of Pathology - University Hospital of Ioannina - Ioannina, Greece , Sintou, Eva Department of Cytology - University Hospital of Ioannina - Ioannina, Greece
Abstract :
Signet-ring cell carcinoma is a highly malignant adenocarcinoma consisting of cells characterized as cytoplasmic vacuoles filledwith mucin. The most common primary location of this type of cancer is the stomach, but it may also be found in other organssuch as prostate, testis, bladder, ovaries, or colon. To date, metastatic signet-ring cell carcinoma of unknown primary (CUP) siteto the testis is an extremely rare entity in daily practice. Reviewing the literature, we have been able to detect only three cases oftesticular metastases from CUP, two with histological diagnosis of a signet-ring cell carcinoma and one with an adenocarcinoma.In this short paper, we report a case of a 56-year-old man who presented to our Department with testicular mass and ascites.Following a standard diagnostic approach no primary tumor could be identified. CUP was the final clinical diagnosis, histologicallycharacterized as poorly differentiated adenocarcinoma with signet-ring cells involving the peritoneum and the testicular structures.
Keywords :
Testicular Signet-Ring Cell Metastasis , Carcinoma , Unknown Primary Site , CUP
