Title of article :
Histiocytic Sarcoma Associated with Coombs Negative AcuteHemolytic Anemia: A Rare Presentation
Author/Authors :
Batra, Sandeep Department of Pediatrics - Section of Pediatric Hematology and Oncology - Riley Hospital for Children at Indiana University Health - Indiana University School of Medicine - Indianapolis - IN 46202, USA , Martin, Stephen C. Department of Pediatrics - Section of Pediatric Hematology and Oncology - Riley Hospital for Children at Indiana University Health - Indiana University School of Medicine - Indianapolis - IN 46202, USA , Nassiri, Mehdi Department of Pathology and Laboratory Medicine - Indiana University School of Medicine - Indianapolis - IN 46202, USA , Qureshi,Amna Department of Pathology and Laboratory Medicine - Indiana University School of Medicine - Indianapolis - IN 46202, USA , Markel, Troy A. Department of Surgery - Section of Pediatric Surgery - Riley Hospital for Children at Indiana University Health - Indiana University School of Medicine - Indianapolis - IN 46202, USA
Abstract :
Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massivesplenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely afteran emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmaskinga clonal heterogeneity within the same neoplasm.
Keywords :
Histiocytic Sarcoma Associated , Coombs Negative Acute Hemolytic Anemia , Rare Presentation , CNHA , NGS , Histiocytic sarcoma (HS)
Journal title :
Case Reports in Oncological Medicine
