Author/Authors :
Johansen, Maria Dinche Department of Radiation Biology - The Finsen Center - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark , Poulsen, Hans Skovgaard Department of Radiation Biology - The Finsen Center - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark , Rochat, Per Department of Neurosurgery - The Neurocenter - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark , Law, Ian Department of Clinical Physiology - Nuclear Medicine and PET - Center of Diagnostic Investigation - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark , Scheie, David Department of Pathology - Center of Diagnostic Investigation - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark , Muhic, Aida Department of Oncology - The Finsen Center - Rigshospitalet - Blegdamsvej - Copenhagen, Denmark
Abstract :
Extracranial metastases from glioblastoma are rare. We report two patients with extracranial metastases from glioblastoma. Case 1concerns a 59-year-old woman with multiple metastases that spread early in the course of disease. What makes this case unusualis that the tumor had grown into the falx close to the straight sinus and this might be an explanation to the early and extensivemetastases. Case 2 presents a 60-year-old man with liver metastasis found at autopsy, and, in this case, it is more difficult to findan explanation. This patient had two spontaneous intracerebral bleeding incidents and extensive bleeding during acute surgerywith tumor removal, which might have induced extracranial seeding. The cases presented might have hematogenous spreading incommon as an explanation to extracranial metastases from GBM.
