Title of article
An Unusual Cause of Subacute Headache ina Patient Undergoing Chemotherapy for Advanced TesticularNonseminomatous Germ Cell Tumour
Author/Authors
Porfiri, Emilio The Cancer Centre - The Queen Elizabeth Hospital - Edgbaston - Birmingham B15 2TH, UK , Clarke, Helen M. The Cancer Centre - The Queen Elizabeth Hospital - Edgbaston - Birmingham B15 2TH, UK , Rao, Ankit R. The Cancer Centre - The Queen Elizabeth Hospital - Edgbaston - Birmingham B15 2TH, UK
Pages
4
From page
1
To page
4
Abstract
Testicular (germ cell) cancer is a model of a chemocurable malignancy and tends to have a favourable prognosis even in advancedstages due to exquisite sensitivity to platinum-based chemotherapy. However, both acute and longer-term toxicities of multiagentchemotherapy remain significant as causes of morbidity, very occasionally mortality, and impaired quality-of-life. Here, we reporta case of acute cerebral venous sinus thrombosis occurring within 10 days of chemotherapy initiation in a young patient withoutcomorbidities, whose only predisposing factors were malignancy, chemotherapy, and perhaps mild dehydration. The clinicalpresentation was also unusual with headache of moderate severity only without focal or global neurologic deficits. We suspect thatcisplatin may have had direct vasculotoxic effects. The patient recovered fully after short-duration anticoagulation but oncologistsmust remain aware of unusual and unpredictable complications of cytotoxic treatment
Keywords
An Unusual Cause , Subacute Headache , Patient Undergoing Chemotherapy , Advanced Testicular Nonseminomatous Germ , Cell Tumour
Journal title
Case Reports in Oncological Medicine
Serial Year
2016
Record number
2612005
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