Adverse Events of the BCG (Bacillus Calmette–Gu ́erin) andRotavirus Vaccines in a Young Infant with InbornError of Immunity

)e Bacillus Calmette–Gu ́erin (BCG) and rotavirus vaccines are live-attenuated preparations. In the United ArabEmirates, these products are universally administered to the young infants. )is unguided practice does not account for thechildren with immunodeficiency, which frequently manifests after the administration of these vaccines. We present here a younginfant with immunodeficiency that developed disseminated tuberculosis infection and severe diarrhea due to these improperimmunizations.Case Presentation. )is young infant was diagnosed at six months of age with “immunodeficiency type 19”(MIM#615617) due to homozygous nonsense variant, NM_000732.4 (CD3D):c.128G>A, p.Trp43∗(variation Clin-Var#VCV000643120.1; pathogenic). )is variant creates premature stop-gain inCD3D(CD3 antigen, delta subunit, autosomalrecessive; MIM#186790), resulting in loss-of-function. He also had “X-linked agammaglobulinemia” (MIM#300755) due tohemizygous missense variant, NM_001287344.1 (BTK):c.80G>A, p.Gly27Asp (novel). He had a sibling who passed away ininfancy of unknown disease and family members with autoimmune disorders. Despite these clear clues, he was immunized withBCG at birth and rotavirus at 2 and 4 months. He was well in the first four months. He then developed high-fever, lymph-adenopathy, and refractory diarrhea. Stool was positive for rotavirus, and lymph node biopsy showed acid-fast bacilli, consistentwith tuberculosis lymphadenitis. )ese infections were serious and markedly complicated his clinical course, which included bonemarrow transplantation from a matched sibling.Conclusions. )ese unfortunate events could have been avoided by compiling theavailable clinical information. )is patient underscores the importance of implementing proper policies for BCG and rotavirusvaccinations. International registries of adverse events of universally administered vaccines are crucial.