Title of article :
Injection Site Erythema in a Patient on TherapeuticAnticoagulation with Low Molecular Weight Heparin afterMechanical Aortic Valve Replacement: A Rare Presentation ofHeparin- and Protamine-Induced Thrombocytopenia
Author/Authors :
Steinlechner, Barbara Division of Cardiothoracic and Vascular Anesthesia and Intensive Care - Medical University of Vienna - Vienna, Austria , Holaubek, Caroline Division of Cardiothoracic and Vascular Anesthesia and Intensive Care - Medical University of Vienna - Vienna, Austria , Simon, Paul Division of Cardiac Surgery - Medical University of Vienna - Vienna, Austria , Gremmel, Franz Division of Cardiac Surgery - Medical University of Vienna - Vienna, Austria , Eichinger-Hasenauer, Sabine Division of Hematology and Hemostaseology - Department of Medicine I - Medical University of Vienna - Vienna, Austria
Abstract :
Previous exposition to heparin and protamine in patients undergoing cardiopulmonary bypass and postoperative therapeuticanticoagulation with LMWH may lead to the development of heparin-induced thrombocytopenia (HIT) and/or protamine-inducedthrombocytopenia(PIT).*iscasedealswith arareclinicalpresentationofcirculatingIgGantibodies againstheparin/plateletfactor4complexesandheparin/protaminecomplexesaftercardiacsurgery.Ensuingpurpuraandskinnecrosis(blisters)at the injection sites of LMWH and clinical symptoms improved rapidly after replacement of LMWH by an alternative anti-coagulant.*eaimofthisreportistodrawattentiontotheseveraldifferentclinicalmanifestationsofheparin-and/orprotamine-induced thrombocytopenia and shows a possible course of treatment and recovery.
Keywords :
Injection Site Erythema , Patient , Therapeutic Anticoagulation , Low Molecular Weight Heparin , Mechanical Aortic Valve Replacement , Rare Presentation , Heparin- and Protamine-Induced Thrombocytopenia , HIT , LMWH
Journal title :
Case Reports in Immunology
