Hereditary Angioedema Type II: First Presentation in Adulthoodwith Recurrent Severe Abdominal Pain

A 27-year-old Emirate man presented to Cleveland Clinic Abu Dhabi emergency department with a 4 year history of recurrentepisodes of severe swellings affecting different parts of his body. He used to get 2 swelling episodes every week affecting either hisface, hands, feet or scrotum and severe abdominal pain twice a week. Abdominal CT scan and a colonoscopy showed bowel walloedema. There was no family history of similar complaint or of hereditary angioedema (HAE). Complement studies confirmed thediagnosis of HAE type II. He was commenced on danazol 100 mg twice daily and his symptoms resolved. This case report highlightsthe importance of considering HAE in patients with recurrent unexplained abdominal pain even in the absence of positive familyhistory of HAE.