Title of article :
Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole
Author/Authors :
Makris ، Michael Second Department of Dermatology and Venereology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens, , Fokoloros ، Christos Second Department of Dermatology and Venereology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens , Syrmali ، Anna Second Department of Dermatology and Venereology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens , Tsakiraki ، Zoi Second Department of Pathology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens , Damaskou ، Vasileia Second Department of Pathology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens , Papadavid ، Evangelia Second Department of Dermatology and Venereology - Medical School, Attikon University Hospital - National and Kapodistrian University of Athens
Abstract :
Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical bullous lesions in previous and new sites after re-administration of the offending drug. We present a well-documented case of fluconazole-induced GBFDE, with a positive patch test to fluconazole (30% weight/volume preparation) and clinical tolerance to itraconazole proven by negative oral provocation. Even in SCARs, patch testing represents a useful diagnostic tool, while oral provocation remains the gold standard in cases that an alternative but the chemically relevant drug must be administered.
Keywords :
Cross reactions , Drug , related side effects and adverse reactions , Fluconazole , Patch tests
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
Journal title :
Iranian Journal of Allergy, Asthma and Immunology
