Giant Condyloma Acuminata in Indonesian Females with SLEunder Immunosuppressant and Steroid Therapy

Immunosuppressant and steroid therapy in systemic lupus erythematosus (SLE) increases the risk of humanpapillomavirus (HPV) infections, one of which is giant condyloma acuminata (GCA). To our knowledge, there is no reportevaluating the correlation between immunosuppressive and steroid therapy in patients with SLE and the prevalence of GCA.CaseReport.A 42-year-old female was diagnosed with SLE a year ago and has been treated with steroids and immunosuppressive drugs.In the last few months she presented GCA involving the genital area recurring almost every two months. Type 6 and 11 HPVs wereidentified in vulva, vagina, and cervix.Methods.PubMed, EBSCO, and Cochrane Library literature were searched from inceptionto July 2015. Authors screened all titles and abstracts and read full text article, and two case-control studies were found relevant.Results.SLE patients in both studies were under immunosuppressive and steroid therapy. Condyloma acuminata was diagnosed at108 months (latest) and 1 month (earliest) after SLE. Type 6, 11, 16, 42, and oncogenic group of HPV were identified.Conclusions.GCA is a type of HPV infection seldom observed in SLE patients. Therefore, their correlation is still unclear. Period of time sinceSLE was diagnosed and GCA varies from months to years. A more thorough physical and laboratory examination leading to HPVand other infectious disease is recommended.