Title of article :
Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats
Author/Authors :
da S. Júnior, Ivanildo I Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , de Moura Barbosa, Humberto Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Carvalho, Débora C. R Federal University of San Francisco Valley - Petrolina - PE - Brazil , de Alencar Barros, Ruideglan Federal University of San Francisco Valley - Petrolina - PE - Brazil , Peixoto Albuquerque, Flávia Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Amaral da Silva, Dionísio Henrique Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Souza, Grasielly R Federal University of San Francisco Valley - Petrolina - PE - Brazil , Souza, Nathália A. C Federal University of San Francisco Valley - Petrolina - PE - Brazil , de Oliveira Júnior, Flávio Monteiro Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Gomes, Dayane A Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Lira, Eduardo C Department of Physiology and Pharmacology - Federal University of Pernambuco - Recife - PE - Brazil , Rolim, Larissa A Federal University of San Francisco Valley - Petrolina - PE - Brazil , Silva, Flaviane M. M Federal University of San Francisco Valley - Petrolina - PE - Brazil
Abstract :
Morus nigra has been used popularly for several proposes, including diabetic. In an attempt to support medicinal value, the acute hypoglycemic, hypolipidemic, and antioxidant effects of the ethanolic extract of Morus nigra (EEMn 200 or 400 mg/kg b.w.) were evaluated in normal and alloxan-induced diabetic treated for 14 days. Serum biochemical and antioxidant analysis were performed
at the end of experiment. Oral glucose tolerance test was performed at 10th and 15th days. Chromatographic analysis by HPLC-DAD of EEMn was performed. Insulin was used as positive control to glycemic metabolism as well as fenofibrate to lipid metabolism.
EEMn (400 mg/kg/day) reduced fasting and postprandial glycaemia, improved oral glucose tolerance, and reduced lipolysis and
proteolysis in diabetic rats. EEMn decreased the blood levels of total cholesterol and increased HDL level when compared to
the diabetic control rats. At higher levels, EEMn reduced triglycerides and VLDL levels in diabetic rats. Also, EEMn reduced
malondialdehyde and increased the reduced glutathione levels in liver of diabetic rats. Chromatographic analysis identified the
presence of the flavonoids rutin, isoquercetin, and kaempferitrin. Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats.
Keywords :
Brazilian Morus nigra , Hyperglycemia , Dyslipidemia , Prooxidant Status , Diabetic Rats
