Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals

Background. Besides the extensive regulatory role in growing number of biologic processes, vitamin D has been recently considered essential for lungs function as well as protective against exacerbation of chronic obstructive pulmonary diseases. We assessed the correlation between vitamin D serum levels with pulmonary function in healthy individuals. Methods. In a cross-sectional study, healthy volunteer (� = 92) participants underwent the following laboratory procedures: a blood test, a 24-hour urine collection test, and the serum level of 25-hydroxy vitamin D before undergoing spirometry. Linear correlation coefcient was calculated to detect the association between serum level of 25-hydroxy vitamin D and pulmonary volumes. Results. Te mean age of participants was 39.95 ± 9.98 years. 48% of participants showed diferent levels of 25-hydroxy vitamin D defciency. We recognized a consistent direct positive correlation between serum levels of 25-hydroxy vitamin D and lung function volumes. The coefcient for forced vital capacity, forced expiratory volume in 1 second, forced expiratory fow 25–75%, and forced expiratory volume in 1 second/forced vital capacity ratio were 0.610, 0.509, 0.454, and 0.551, respectively. Conclusions. Our fndings suggest correlation between higher serum levels of 25-hydroxy vitamin D and improved pulmonary function. Accordingly, supplemental vitamin D might signifcantly improve treatment response.