Author/Authors :
Habran, Simon University of Liège - GIGA-In Silico Medicine, Belgium , Desaive, Thomas University of Liège - GIGA-In Silico Medicine, Belgium , Morimont, Philippe University of Liège - GIGA-In Silico Medicine, Belgium , Lambermont, Bernard University of Liège - GIGA-Cardiovascular Sciences, Belgium , Dauby, Pierre C University of Liège - GIGA-In Silico Medicine, Belgium
Abstract :
Venoarterial extracorporeal life support (VA-ECLS) is used in ICUs (intensive care units) for the most extreme presentations of
acute and severe cardiogenic shock, and one of the main issues the clinicians have to deal with is the weaning from VA-ECLS.
In this study, a patient-specific model of the cardiovascular system connected to a VA-ECLS is built to improve the
understanding of this complex system. Pig experiments are performed to validate the model, and the results are quite promising
since the mean difference between experimental data and simulation is smaller than 5% for all the hemodynamic quantities. It is
also a major objective of this paper to provide a proof-of-concept analysis that model-based approaches could improve the
weaning strategy for VA-ECLS therapy.
Keywords :
VA-ECLS , Model-Based , Therapy , ICU
