Author/Authors :
Ono, Yuko Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Shimo, Tsuyoshi Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Shirafuji, Yoshinori Department of Dermatology - Okayama University Graduate School of Medicine - Dentistry and Pharmaceutical Sciences, Okayama, Japan , Hamada, Toshihisa Department of Dermatology - Okayama University Graduate School of Medicine - Dentistry and Pharmaceutical Sciences, Okayama, Japan , Masui, Masanori Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Obata, Kyoichi Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Yao, Mayumi Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Kishimoto, Koji Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan , Sasaki, Akira Department of Oral and Maxillofacial Surgery - Okayama University Graduate School of Medicine- Dentistry and Pharmaceutical Sciences, Okayama, Japan
Abstract :
An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6
weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced
hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed
acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6
(HHV-6) IgG, and CMV-HRP were negative. Oral prednisolone therapy was begun 18 days later. The titer of HHV-6 IgG antibodies
was then detected (640 times). Following treatment, liver and renal function improved and the erythema disappeared.
Keywords :
Drug-Induced Hypersensitivity , Syndrome , Carbamazepine , Trigeminal Neuralgia
