Author/Authors :
Amorim, Elias Department of Surgery - Universidade Federal do Maranhão (UFMA), Sao Luis-MA, Brazil , Saad, Roberto Hospital da Santa Casa de São Paulo. Head - Thoracic Surgery Service, Santa Casa de São Paulo, Brazil , Salgado, Natalino UFMA, Sao Luis-MA, Brazil , Melo, George Castro Figueira de UFMA, Sao Luis-MA, Brazil , Silva, Gyl Eanes Barros UFMA, Sao Luis-MA, Brazil , Santos, Rennan Abud Pinheiro School of Medicine - UFMA, Sao Luis-MA, Brazil , Marchi, Danilo Dallago de School of Medicine - UFMA, Sao Luis-MA, Brazil , Carli, Ricardo Comunello de School of Medicine - UFMA, Sao Luis-MA, Brazil , Malafaia, Osvaldo Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil , Ribas-Filho, Jurandir FEPAR, Curitiba-PR, Brazil
Abstract :
PURPOSE:
To evaluate macro and microscopically, changes following the use of the aqueous extract of babassu (Orbignya phalerata) in the lung parenchyma and pleura of rats.
METHODS:
Sixty adult male rats with average weight of 350 g, were randomized into two groups of 30 animals (experimental and control) further divided into sub-groups of 10 to be sacrificed at 48 h, 72 h and 21 days. The substance was injected into the right pleura of the animals.
RESULTS:
There was intense pleuropulmonary macroscopic reaction with statistically significant differences between groups respectively (p<0.05, p<0.02, p<0.03). Microscopically, no statistically significant difference was evident (p>0.05).
CONCLUSION:
The aqueous extract of babassu (Orbignya phalerata) was found to be highly irritating to the pleura and lung of rats, evidenced macroscopically by numerous adhesions and inflammation while no major changes were evident microscopically.
Keywords :
Plants , Medicinal , Phytotherapy , Pleura , Lung , Rats
