Author/Authors :
Maria Oliveira Brito, Luciane Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , Oliveira Brito, Haissa Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , da Graça Carvalhal Frazão Corrêa, Rita Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , de Oliveira Neto, Clariano Pires Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , Leal Costa, Joyce Pinheiro Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , Moutinho Monteiro, Sally Cristina Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , Castello Branco Vidal, Flávia Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , do Desterro Soares Brandão Nascimento, Maria Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , de Figueiredo Neto, José Albuquerque Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , da Costa, Rui Miguel Gil Molecular Oncology and Viral Pathology Group - Portuguese Institute of Oncology - Porto - Portugal , Galvão-Moreira, Leonardo Victor Tumor and DNA Biobank of Maranhao - Federal University of Maranh ˜ ao - S ˜ ao Lu ˜ ´ıs - Brazil , Guerreiro da Silva, Ismael Dale Cotrim Federal University of Sao Paulo - S ˜ ao Paulo - Brazil
Abstract :
Background
Cardiovascular diseases are leading causes of death worldwide. Recent studies suggest that infection by some viruses, including the human papillomavirus (HPV), may increase the risk of developing atheromatous lesions on coronary arteries. However, there is a lack of data regarding the possible association between HPV infection and coronary artery disease (CAD) in women.
Objective
To investigate whether HPV infection is associated with the occurrence of CAD among climacteric women.
Methods
The presence of CAD and cervical HPV DNA was investigated in 52 climacteric women. Social and demographic variables and metabolic profiles were also investigated.
Results
Among 27 women with CAD, 16 were positive for HPV, whereas 11 were negative. The presence of cervical HPV was strongly associated with CAD, after adjusting for demographic variables, health and sexual behaviors, comorbidities, and known cardiovascular risk factors. HPV-positive women showed a greater likelihood of having CAD (odds ratio [OR] = 3.74; 95% confidence interval [CI]: 1.16 to 11.96) as compared with HPV-negative women, particularly those infected with high-risk HPV types (OR = 4.90; 95% CI: 1.26 to 19.08). Conclusion
These results support the hypothesis that HPV infection might be associated with CAD among climacteric women, though further studies are needed to investigate the mechanisms involved.
Keywords :
CAD , HPV DNA , human papillomavirus (HPV) , Human Papillomavirus , Coronary Artery Disease , Climacteric Women
