Author/Authors :
Sousa, Eros Luiz de Pontificia Universidade Católica do Paraná (PUCPR), Curitiba-PR, Brazil , Wouk, Antônio Felipe Paulino de Figueiredo PUCPR, Curitiba-PR, Brazil , Malafaia, Osvaldo Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil , Ribas-Filho, Jurandir Marcondes Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil , Noronha, Lucia PUCPR, Curitiba-PR, Brazil , Cirio, Silvana Maris FEPAR, Curitiba-PR, Brazil , PimpãoVII, Claudia Turra PUCPR, Curitiba-PR, Brazil , Marinho, Carlos Hespanha FEPAR, Curitiba-PR, Brazil , Torres, Maria Fernanda School of Veterinary Medicine - Universidade Federal do Paraná (UFPR), Curitiba-PR, Brazil , Graça, Yorgos Luiz Santos de Salles School of Medicine - FEPAR, Curitiba-PR, Brazil , Ferrarin, Daniel Dantas Hospital Angelina Caron, Campina Grande do Sul-PR, Brazil
Abstract :
PURPOSE :
To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use.
METHODS:
Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9.
RESULTS:
Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods.
CONCLUSION:
The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Keywords :
Wound Healing , Intestine , Small , Anti-Inflammatory Agents , Rats
