Title of article :
The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats
Author/Authors :
Melekoglu, Rauf Department of Obstetrics and Gynaecology - Faculty of Medicine - University of Inonu, Malatya, Turkey , Ciftci, Osman Department of Medical Pharmacology - Faculty of Medicine - University of Inonu, Malatya, Turkey , Cetin, Aslı Department of Histology - Faculty of Medicine - University of Inonu, Malatya, Turkey , Basak, Nese Department of Pharmaceutical Toxicology - Faculty of Pharmacy - University of Inonu, Malatya, Turkey , Celik, Ebru Department of Obstetrics and Gynaecology - Faculty of Medicine - University of Inonu, Malatya, Turkey
Abstract :
PURPOSE:
To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.
METHODS:
Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.
RESULTS:
The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.
CONCLUSION:
The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.
Keywords :
Tetrachlorodibenzodioxin , Oxidative Stress , Leukotriene Antagonists , Ovary , Uterus
Journal title :
Acta Cirurgica Brasileira
