Author/Authors :
Yamaguchi, Tetsutaro Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Shirota, Tatsuo Department of Oral and Maxillofacial Surgery - School of Dentistry - Showa University, Tokyo, Japan , Adel, Mohamed Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Takahashi, Masahiro Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Haga, Shugo Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Nagahama, Ryo Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Nakashima, Misato Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Furuhata, Mayu Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan , Kamatani, Takaaki Department of Oral and Maxillofacial Surgery - School of Dentistry - Showa University, Tokyo, Japan , Mak, Koutaro Department of Orthodontics - School of Dentistry - Showa University, Tokyo, Japan
Abstract :
Williams–Beuren syndrome (WBS) is a rare multisystem disorder caused by a hemizygous deletion of the elastin gene on
chromosome 7q11.23. WBS patients have characteristic skeletal features and dental anomalies accompanied by mental retardation,
a friendly outgoing personality, and mild to moderate intellectual disability or learning problems. In this case report, we present the
combined orthodontic and surgical treatment of a WBS patient with an isolated cleft palate through a long-term follow-up from the
age of 5 to 24 years. During the period of active treatment, comprehensive orthodontic treatment combined with maxillary anterior
segmental distraction osteogenesis and prosthetic treatment using dental implants were effective in dramatically improving the
patient’s malocclusion. The patient’s mental abilities and the cooperation shown by the patient and her family were crucial for the
success of this complex and long-term treatment course.
Keywords :
Orthodontic Treatment , Maxillary Anterior Segmental , Syndrome , Isolated Cleft Palate , Distraction Osteogenesis
