Author/Authors :
McNeil, Matthew B. TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Chettiar, Somsundaram TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Awasthi, Divya TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA , Parish, Tanya TB Discovery Research - Infectious Disease Research Institute, Seattle, WA, USA
Abstract :
There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.
Keywords :
mycobacteria , permeability , tuberculosis , rifampicin , Mycobacterium tuberculosis
