Author/Authors :
Camargo, Cristina Pires Faculty of Medicine - Universidade de São Paulo (FMUSP), Brazil , Fernandes, Felipe Alexandre School of Medicine - USP, Sao Paulo-SP, Brazil , Lee, Michel Hyo Mi School of Medicine - USP, Sao Paulo-SP, Brazil , Silva, Luiza Campos Moreira School of Medicine - USP, Sao Paulo-SP, Brazil , Besteiro, Julio Morais Department of Plastic Surgery - FMUSP, Sao Paulo-SP, Brazil , Gemperli, Rolf Department of Surgery - FMUSP, Sao Paulo-SP, Brazil
Abstract :
PURPOSE:
To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure.
METHODS:
60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio.
RESULTS:
This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03).
CONCLUSIONS:
Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
Keywords :
Surgical Flaps , Botulinum Toxins , Type A , Survival , Tobacco , Rats
