Author/Authors :
Ohashi, Camila Melo Department of Surgery - Universidade Federal do Pará (UFPA), Belem-PA, Brazil , Caldeira, Fabio Alves Morikawa Department of Surgery - Universidade Federal do Pará (UFPA), Belem-PA, Brazil , Feitosa-Junior, Denilson José Silva Department of Integrated Health - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Valente, André Lopes Department of Integrated Health - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Dutra, Paulo Roberto Witter Department of Biology - UFPA, Belem-PA, Brazil , Miranda, Moysés dos Santos Department of Biological Sciences - UFPA, Belem-PA, Brazil , Santos, Simone do Socorro Damasceno Department of Histology and Embriology - UFPA, Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Integrated Health - UEPA, Belem-PA, Brazil , Ohashi, Otávio Mitio Department of Biological Sciences - UFPA, Belem-PA, Brazil , Yasojima, Edson Yuzur Department of Surgery - UFPA, Belem-PA, Brazil
Abstract :
PURPOSE:
To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats.
METHODS:
Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed.
RESULTS:
All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions.
CONCLUSION:
Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
Keywords :
Adipose Tissue , Wound Healing , Stem Cells , Rats
