Title of article :
B Cell Regulation in Autoimmune Diseases
Author/Authors :
Sokolov, A.V Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Shmidt, A.A Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Lomakin, Y.A Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia
Abstract :
Antibody-independent B cell effector functions play an important role in the development and sup-pression of the immune response. An extensive body of data on cytokine regulation of the immune response by B lymphocytes has been accumulated over the past fifteen years. In this review, we focused on the mechanisms of inflammatory response suppression by subpopulations of regulatory B cells in health and autoimmune pathol-ogies
Keywords :
Multiple sclerosis , systemiclupuserythematosus , CD19+CD24(hi)CD38(hi) , IL-35 , regulatory B cells , Breg , experimental autoimmune encephalomyelitis , rheumatoid arthritis , IL-10
Journal title :
Acta Naturae
