Author/Authors :
Sauter, Alexander W University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland , Stieltjes, Bram University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland , Weikert, Thomas University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland , Gatidis, Sergios University Hospital Tubingen - Eberhard Karls University - Hoppe-Seyler-Straße - Tubingen, Germany , Wiese, Mark University Hospital Basel - University of Basel - Clinic of Thoracic Surgery - Spitalstrasse - Basel, Switzerland , Klarhöfer, Markus Siemens Healthineers - Freilagerstrasse - Zurich, Switzerland , Bremerich, Jens University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland , Wild, Damian University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland , Lardinois, Didier University Hospital Basel - University of Basel - Clinic of Thoracic Surgery - Spitalstrasse - Basel, Switzerland , Sommer, Gregor University Hospital Basel - University of Basel - Clinic of Radiology & Nuclear Medicine - Petersgraben - Basel, Switzerland
Abstract :
The minimum apparent diffusion coefficient (ADCmin) derived from diffusion-weighted MRI (DW-MRI) and the maximum
standardized uptake value (SUVmax) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the
two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI
coregistration, values and location of ADCmin- and SUVmax-voxels were analyzed. The upper limit of the 95% confidence interval
for registration accuracy of sequential PET/MRI was 12 mm, and the mean distance (𝐷) between ADCmin- and SUVmax-voxels
was 14.0 mm (average of two readers). Spatial mismatch (𝐷 > 12 mm) between ADCmin and SUVmax was found in 9/25 patients.
A considerable number of mismatch cases (65%) was also seen in a control group that underwent simultaneous PET/MRI. In the
entire patient cohort, no statistically significant correlation between SUVmax and ADCmin was seen, while a moderate negative linear
relationship (𝑟 = −0.5) between SUVmax and ADCmin was observed in tumors with a spatial match (𝐷 ≤ 12 mm). In conclusion,
spatial mismatch between ADCmin and SUVmax is found in a considerable percentage of patients. The spatial connection of the two
parameters SUVmax and ADCmin has a crucial influence on their numeric correlation.
Keywords :
PET/MRI , 18F-Fluorodeoxyglucose , ADC , Uptake
