Author/Authors :
Palikov, V.A Branch of the Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow region, Russia , Terekhov, S.S Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Palikova, Yu.A Branch of the Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow region, Russia , Khokhlova, O.N Branch of the Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow region, Russia , Kazakov, V.A Branch of the Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow region, Russia , Dyachenko, I.A Branch of the Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow region, Russia , Panteleev, S.V Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Mokrushina, Yu.A Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Knorre, .D Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Shamborant, O.G Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Smirnov, I.V Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia , Gabibov, A.G Institute of Bioorganic Chemistry - Academicians M.M. Shemyakin and Yu.A. Ovchinnikova RAS, Moscow, Russia
Abstract :
The development of antidotes to organophosphate poisons is an important aspect of modern phar-macology. Recombinant acetylcholinesterase and butyrylcholinesterase are effective DNA-encoded acceptors of organophosphate poisons and, in particular, pesticides. Here, we present the results of a study on the effec-tiveness of recombinant butyrylcholinesterase (BChE) in modeling organophosphate poisoning caused by oral administration of paraoxon at a dose of 2 mg / kg. The study showed a high activity of BChE as a protective agent for subchronic anticholinesterase poisoning in an in vivo model. The administration of BChE in a dose of 20 mg / kg allows one to avoid mortality, and also contributed to rapid recovery after model poisoning.
