Author/Authors :
Feitosa, Marley Ribeiro Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Féres, Omar Medical School of the Barão de Mauá University Center, Brazil , Tamaki, Camila Mussolin Hyperbaric Medicine Center, São Paulo, Brazil , Perazzoli, Camila Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Bernardes, Mário Vinícius Angelete Alvarez Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Parra, Rogério Serafim Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Rocha, José Joaquim Ribeiro da Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil , Féres, Omar Department of Surgery and Anatomy - Ribeirão Preto Medical School - University of São Paulo, Brazil
Abstract :
PURPOSE:
To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease.
METHODS:
A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease.
RESULTS:
A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%.
CONCLUSION:
Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.
Keywords :
Hyperbaric Oxygenation , Crohn Disease , Cutaneous Fistula , Pyoderma Gangrenosum
