Author/Authors :
Oliveira, Rita de Cássia Silva de Department of Pharmacology - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Experimental Surgery - UEPA, Belem-PA, Brazil , Ribeiro, Rubens Fernando Gonçalves UEPA, Belem-PA, Brazil , Oliveira, Leonam Oliver Durval UEPA, Belem-PA, Brazil , Monteiro, Andrew Moraes School of Medicine - UEPA, Belem-PA, Brazil , Brandão, Fernando Mateus Viegas School of Medicine - UEPA, Belem-PA, Brazil , Cavalcante, Lainy Carollyne da Costa School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil , Gouveia, Eduardo Henrique Herbster School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil , Henriques, Higor Yuri Bezerra School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil
Abstract :
Purpose:
To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.
Methods:
Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion.
Results:
Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue.
Conclusion:
Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.
Keywords :
Tramadol , Ischemia , Reperfusion , Oxidative Stress , Kidney , Rats
