Author/Authors :
Corrêa, Mikaela da Silva Department of Gynecology and Obstetrics - Botucatu Medical School - Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil , Gelaleti, Rafael Bottaro Department of Gynecology and Obstetrics - Botucatu Medical School - Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil , Bento, Giovana Fernanda Botucatu Medical School - Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil , Damasceno, Débora Cristina Department of Gynecology and Obstetrics - Botucatu Medical School - Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil , Peraçoli, José Carlos Department of Gynecology and Obstetrics - Botucatu Medical School - Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil
Abstract :
Purpose:
To evaluate DNA damage levels in pregnant rats undergoing a treadmill exercise program.
Methods:
Wistar Kyoto rats were allocated into two groups (n= 5 animals/group): non-exercise and exercise. The pregnant rats were underwent an exercise protocol on a treadmill throughout pregnancy. Exercise intensity was set at 50% of maximal capacity during maximal exercise testing performed before mating. Body weight, blood pressure and glucose levels, and triglyceride concentration were measured during pregnancy. At day 10 post-natal, the animals were euthanized and maternal blood samples were collected for DNA damage.
Results:
Blood pressure and glucose levels and biochemical measurements showed no significant differences. Increased DNA damage levels were found in exercise group compared to those of non-exercise group (p<0.05).
Conclusion:
The exercise intensity protocol used in the study might have been exhaustive leading to maternal increased DNA damage levels, demonstrating the relevance of an adequate protocol of physical exercise.
Keywords :
Pregnancy , Exercise , DNA Damage , Rats
