Author/Authors :
Mouss, Khadija Ait Department of Microbiology - Faculty of Medicine and Pharmacy - Hassan II University of Casablanca, 19 rue Tarik Bnou Zyad, 20360, Casablanca, Morocco , Razki, Aziza Institut Pasteur du Maroc, place louis pasteur, 20360, Casablanca, Morocco , Hong, Eva Institut Pasteur - Invasive Bacterial Infections Unit, Paris, France , Zaki, Bahija Bacteriology-Virology and Hospital Hygiene Laboratory - University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco , Maaloum, Fakhreddine Department of Microbiology - Faculty of Medicine and Pharmacy - Hassan II University of Casablanca, 19 rue Tarik Bnou Zyad, 20360, Casablanca, Morocco , Nzoyikorera, Néhémie Department of Microbiology - Faculty of Medicine and Pharmacy - Hassan II University of Casablanca, 19 rue Tarik Bnou Zyad, 20360, Casablanca, Morocco , Belabbes, Houria Department of Microbiology - Faculty of Medicine and Pharmacy - Hassan II University of Casablanca, 19 rue Tarik Bnou Zyad, 20360, Casablanca, Morocco , Elmdaghri, Naima Bacteriology-Virology and Hospital Hygiene Laboratory - University Hospital Centre Ibn Rochd, 1, Rue des Hôpitaux, Casablanca, Morocco , Zerouali, Khalid Department of Microbiology - Faculty of Medicine and Pharmacy - Hassan II University of Casablanca, 19 rue Tarik Bnou Zyad, 20360, Casablanca, Morocco
Abstract :
Surveillance of invasive meningococcal diseases (IMD) must be carried out regularly and continuously in order to detect the emergence of strains of reduced susceptibility to antibiotics for therapeutic and prophylactic use and the appearance of new invasive clones. Molecular-typing approaches allow reliable traceability and powerful epidemiological analysis. This is an epidemiological study of Neisseria meningitidis causing meningitis in Casablanca, Morocco. The grouping was confirmed by PCR mainly on the isolates from cerebrospinal fluid (CSF). A total of 245 confirmed isolates of N .meningitidis were obtained between 2010 and 2019 of which 93 % are of group B. Overall, 24 % of all the isolates have a reduced susceptibility to penicillin G, but no resistance to penicillin G has been reported. All the isolated strains are susceptible to third-generation cephalosporins (3GCs). Genotyping by multilocus sequence typing (MLST) of a selection of 18 strains showed that the majority of isolates belong to the invasive clonal complex CC 32(9/18) followed by the CC 41/44(3/18).
