Author/Authors :
Onay, Aslihan Department of Radiology - Koc University School of Medicine - Istanbul, Turkey , Ertas, Gokhan Department of Biomedical Engineering - Yeditepe University - Istanbul, Turkey , Vural, Metin Department of Radiology - VKF American Hospital - Istanbul, Turkey , Acar, Omer Department of Urology - Koc University School of Medicine - Istanbul, Turkey , Saglican, Yesim Department of Pathology - Acibadem University School of Medicine - Istanbul, Turkey , Coskun, Bilgen Department of Radiology - VKF American Hospital - Istanbul, Turkey , Akpek, Sergin Department of Radiology - Koc University School of Medicine - Istanbul, Turkey
Abstract :
To evaluate the aggressiveness of peripheral zone prostate cancer by correlating the Gleason score (GS) with the ratio of the
diffusion tensor imaging (DTI) measures. Materials and Methods. Forty-two peripheral zone prostate tumors were imaged using
DTI. Regions of interest focusing on the center of tumor foci and noncancerous tissue were used to extract statistical measures of
mean diffusivity (MD) and fractional anisotroy (FA). Measure ratio was calculated by dividing tumor measure by noncancerous
tissue measure. Results. Strong correlations are observable between GS and MD measures while weak correlations are present
between GS and FA measures. Minimum tumor MD (MDmin) and the ratio of minimum MD (rMDmin) show the same highest
correlation with GS (both 𝜌 = −0.73). Between GS ≤ 7 (3 + 4) and GS ≥ 7 (4 + 3), differences are significant for all MD measures
but for some FA measures. MD measures perform better than FA measures in discriminating GS ≥ 7 (4 + 3). Conclusion. Ratios
of MD measures can be used in evaluation of peripheral zone prostate cancer aggressiveness; however tumor MD measures alone
perform similarly
