Author/Authors :
Feng, Shi-Ting Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Zhu, Hongzhang Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Peng, Zhenpeng Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Huang, Li Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Dong, Zhi Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Xu, Ling Faculty of Medicine and Dentistry - University of Western Australia - Perth, Australia , Huang, Kun Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Yang, Xufeng Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Lin, Zhi Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China , Li, Zi-Ping Department of Radiology - The First Affiliated Hospital - Sun Yat-sen University - The Second Zhongshan Road, Guangzhou - Guangdong, China
Abstract :
To investigate the effectiveness of a new individualized contrast medium injection protocol for enhanced liver CT scan.
Methods. 324 patients who underwent plain and dual phase enhanced liver CT were randomly assigned to 2 groups: G1 (𝑛 = 224,
individualized contrast medium injection protocol); G2 (𝑛 = 100, standard contrast medium injection with a dose of 1.5 ml/kg). CT
values and ΔHU (CT values difference between plain and enhanced CT) of liver parenchyma and tumor-liver contrast (TLC) during
hepatic arterial phase (HAP) and portal venous phase (PVP) and contrast medium dose were measured. The tumor conspicuity of
hepatocellular carcinoma (HCC) between two groups was independently evaluated by two radiologists. Results. The mean contrast
medium dose of G1 was statistically lower than that of G2.There were no significantly statistical differences in CT values and ΔHU of
liver parenchyma during HAP, TLC values during HAP, and PVP between two groups.The CT values and ΔHU of liver parenchyma
during PVP of G2 were significantly higher than those of G1. Two independent radiologists were both in substantial conformity in
grading tumor conspicuity. Conclusion. Using the individually optimized injection protocol might reduce contrast medium dose
without impacting on the imaging quality in enhanced liver CT.
Keywords :
CT , Protocol , Enhanced , ICM
