Author/Authors :
Dai, Dong Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Song, Xiuyu Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Wang, Man Xuan Wu Hospital - Capital Medical University - Beijing, China , Li, Lin Beijing Engineering Research Center of Radiographic Techniques and Equipment - Beijing, China , Ma, Wenchao Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Xu, Wengui Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Ma, Yunchuan Xuan Wu Hospital - Capital Medical University - Beijing, China , Liu, Juntian Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Zhang, Jin Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Liu, Peifang Department of Molecular Imaging and Nuclear Medicine and Key Laboratory of Cancer Prevention and Therapy and Key Laboratory of Breast Cancer Prevention and Therapy - Tianjin Medical University Cancer Institute and Hospital - National Clinical Research Center for Cancer - Tianjin, China , Gu, Xiaoyue Beijing Engineering Research Center of Radiographic Techniques and Equipment - Beijing, China , Su, Yusheng Xuan Wu Hospital - Capital Medical University - Beijing, China
Abstract :
To compare the diagnostic performance of three-dimensional (3D) positron emission mammography (PEM) versus
whole body positron emission tomography (WBPET) for breast cancer. Methods. A total of 410 women with normal breast or
benign or highly suspicious malignant tumors were randomized at 1 : 1 ratio to undergo 3D-PEM followed by WBPET or WBPET
followed by 3D-PEM. Lumpectomy or mastectomy was performed on eligible participants after the scanning.Results.The sensitivity
and specificity of 3D-PEM were 92.8% and 54.5%, respectively. WBPET showed a sensitivity of 95.7% and specificity of 56.8%. After
exclusion of the patients with lesions beyond the detecting range of the 3D-PEM instrument, 3D-PEM showed higher sensitivity
thanWBPET (97.0% versus 95.5%, P = 0.913), particularly for small lesions (<1 cm) (72.0% versus 60.0%, P = 0.685).Conclusions.The
3D-PEM appears more sensitive to small lesions than WBPET but may fail to detect lesions that are beyond the detecting range.This
study was approved by the Ethics Committee (E2012052) at the Tianjin Medical University Cancer Institute and Hospital (Tianjin,
China). The instrument positron emission mammography (PEMi) was approved by China State Food and Drug Administration
under the registration number 20153331166.
Keywords :
Body , Tomography , Mammography , WBPET , China
