Author/Authors :
Paramonova, M.P Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia , Khandazhinskaya, A.L Engelhardt Institute of Molecular Biology - Russian Academy of Science, Moscow, Russia , Ozerov, A.A Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia , Kochetkov, S.N Engelhardt Institute of Molecular Biology - Russian Academy of Science, Moscow, Russia , Snoeck, R Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium , Andrei, G Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium , Novikov, M.S Department of Pharmaceutical & Toxicological Chemistry - Volgograd State Medical University, Volgograd, Russia
Abstract :
series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.
Keywords :
varicella zoster virus , human cytomegalovirus , antiviral activity , synthesis , 4-oxoquinazoline , Uracil derivatives
