Author/Authors :
Feitosa, Matheus Levi Tajra Department of Surgery - Faculty of Veterinary Medicine and Animal Science - Universidade de São Paulo (USP), Brazil , Sarmento, Carlos Alberto Palmeira Department of Surgery - Faculty of Veterinary Medicine and Animal Science - Universidade de São Paulo (USP), Brazil , Bocabello, Renato Zonzini Department of Surgery - Faculty of Veterinary Medicine and Animal Science - Universidade de São Paulo (USP), Brazil , Beltrão-Braga, Patrícia Cristina Baleeiro Department of Surgery - USP, Sao Paulo-SP, Brazil , Pignatari, Graciela Conceição Department of Surgery - Faculty of Veterinary Medicine and Animal Science - USP, Sao Paulo-SP, Brazil , Giglio, Robson Fortes Department of Clinical Sciences - University of Florida, Gainesville, Florida, USA , Miglino, Maria Angelica Department of Veterinary Medicine - Faculty of Animal Science and Food Engineering - USP, Pirassunung-SP, Brazil , Orlandin, Jéssica Rodrigues Veterinary Medicine Department - Faculty of Animal Science and Food Engineering - USP, Pirassununga-SP, Brazil , Ambrósio, Carlos Eduardo Veterinary Medicine Department - Faculty of Animal Science and Food Engineering - USP, Pirassununga-SP, Brazil
Abstract :
Purpose:
To investigate the therapeutic potential of human immature dental pulp stem cells in the treatment of chronic spinal cord injury in dogs.
Methods:
Three dogs of different breeds with chronic SCI were presented as animal clinical cases. Human immature dental pulp stem cells were injected at three points into the spinal cord, and the animals were evaluated by limb function and magnetic resonance imaging (MRI) pre and post-operative.
Results:
There was significant improvement from the limb function evaluated by Olby Scale, though it was not supported by the imaging data provided by MRI and clinical sign and evaluation.
Conclusion:
Human dental pulp stem cell therapy presents promising clinical results in dogs with chronic spinal cord injuries, if used in association with physical therapy.
Keywords :
Cell- and Tissue-Based Therapy , Spinal Cord Injuries , Dental Pulp , Dogs
