Author/Authors :
Mannucci, Silvia Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Tambalo, Stefano Consorzio INSTM - Via G. Giusti - Firenze, Italy , Conti, Giamaica Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Ghin, Leonardo Department of Biotechnology - University of Verona, Strada Le Grazie - Verona, Italy , Milanese, Alessio Consorzio INSTM - Via G. Giusti - Firenze, Italy , Carboncino, Anna Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Nicolato, Elena Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Marinozzi, Maria Rosaria Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Benati, Donatella Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy , Bassi, Roberto Department of Biotechnology - University of Verona, Strada Le Grazie - Verona, Italy , Marzola, Pasquina Department of Computer Science - University of Verona - Strada Le Grazie - Verona, Italy , Sbarbati, Andrea Department of Neuroscience - Biomedicine and Movement Sciences - University of Verona - Strada Le Grazie - Verona, Italy
Abstract :
Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor
cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic
nanoparticles naturally produced by magnetotactic bacteria: magnetosomes. e eficacy of such protocol is tested in a xenograft
model of glioblastoma. Mice receive a single intratumoral injection of magnetosomes, and they are exposed three times in a week to
an alternating magnetic field with concurrent temperature measurements. MRI is used to visualize the nanoparticles and to monitor
tumor size before and after the treatment. Statistically significant inhibition of the tumor growth is detected in subjects exposed to the
alternating magnetic field compared to control groups. Moreover, thanks to magnetosomes high transversal relaxivity, their effective
delivery to the tumor tissue is monitored by MRI. It is apparent that the eficacy of this protocol is limited by inhomogeneous delivery
of magnetosomes to tumor tissue. ese results suggest that naturally synthesized magnetosomes could be effectively considered as
theranostic agent candidates for hyperthermia based on iron oxide nanoparticles.
