Author/Authors :
Khatri, Akshay M. Division of Infectious Diseases - Department of Medicine - Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, New York, USA , Rai, Shipra Department of Pediatrics - Steven and Alexandra Cohen Children’s Medical Center - Northwell Health, New Hyde Park, New York, USA , Shank, Caroline Department of Pediatrics - Steven and Alexandra Cohen Children’s Medical Center - Northwell Health, New Hyde Park, New York, USA , McInerney, Alissa Division of Allergy and Immunology - Department of Pediatrics - Northwell Health, Manhasset, New York, USA , Kaplan, Blanka Division of Allergy and Immunology - Department of Pediatrics - Northwell Health, Manhasset, New York, USA , Hagmann, Stefan H. F. Department of Pediatrics - Steven and Alexandra Cohen Children’s Medical Center - Northwell Health, New Hyde Park, New York, USA , Kainth, Mundeep K. Department of Pediatrics - Steven and Alexandra Cohen Children’s Medical Center - Northwell Health, New Hyde Park, New York, USA
Abstract :
Introduction
Bacillus clausii as a probiotic supplement is increasingly used in both adult and paediatric patient populations. There is limited awareness about potential adverse effects.
Case presentation
We report a case of prolonged (111 days) B. clausii bacteraemia after brief probiotic use in a 17-month-old immunocompetent child, without a definite focus of infection and in the absence of predisposing risk factors or underlying co-morbidities. We identified seven probiotic use-associated cases of prolonged B. clausii bacteraemia (mean duration [range] 64 days [14–93 days] where data were available) in the literature, all with underlying co-morbidities.
Conclusion
B. clausii probiotic preparations may cause prolonged bacteraemia, rendering patients with underlying co-morbidities as well as those with unrecognized risk factors vulnerable for significant infectious complications.
