Author/Authors :
Costa, Eduardo Louzada da Department of Orthopedics - Universidade Federal de Minas Gerais (UFMG), Belo Horizonte-MG, Brazil , Teixeira, Luiz Eduardo Moreira Department of Locomotive Apparatus - UFMG, Belo Horizonte-MG, Brazil , Pádua, Bruno Jannotti Department of Orthopedics - UFMG, Belo Horizonte-MG, Brazil , Araújo, Ivana Duval de Department of Surgery - UFMG, Belo Horizonte-MG, Brazil , Vasconcellos, Leonardo de Souza Pharmacy Department - UFMG, Belo Horizonte-MG, Brazil , Dias, Luide Scalioni Borges School of Medicine - UFMG, Belo Horizonte-MG, Brazil
Abstract :
Purpose:
To evaluate the use of platelet-rich plasma in the early stages of healing of traumatic injury of the medial collateral ligament in the knee of rabbits.
Methods:
Thirty rabbits were subjected to surgical lesion of the medial collateral ligament. Of these, 16 were treated with platelet-rich plasma and 14 with saline (control). After 3 and 6 weeks of treatment, 50% of the animals from each group were sacrificed, and biomechanical tests were performed on the injured ligament to compare the tensile strength between the two groups.
Results:
Platelet-rich plasma significantly increased the tensile strength of the ligament in the groups treated after3 and 6 weeks. In the group treated with platelet-rich plasma vs. saline, the tensile strength values were 3192.5 ± 189.7 g/f vs. 2851.1 ± 193.1 g/f at3 weeks (p = 0.005) and 5915.6 ± 832.0 g/f vs. 4187.6 ± 512.9 g/f at 6 weeks (p = 0.0001).
Conclusion:
The use of platelet-rich plasma at the injury site accelerated ligament healing in an animal model, demonstrated by an increase in the tensile strength of the medial collateral ligament.
Keywords :
Medial Collateral Ligament , Knee , Knee Injuries , Rabbits
