• Title of article

    Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

  • Author/Authors

    Ribeiro, Rubens Fernando Gonçalves Universidade Estadual do Para (UEPA), Brazil , Couteiro, Rodrigo Paracampo School of Medicine - UEPA, Belem-PA, Brazil , Monteiro, Andrew Moraes School of Medicine - UEPA, Belem-PA, Brazil , Rodrigues, Ivone Aline da Silva School of Medicine - UEPA, Belem-PA, Brazil , Cavalcante, Lainy Carollyne da Costa School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Gouveia, Eduardo Henrique Herbster School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Galvão, Lucas Nascimento School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Brazil , Lopes, Luiz Renato Oliveira School of Medicine - UEPA, Belem-PA, Brazil , Yasojima, Edson Yuzur Department of Experimental Surgery - UEPA, Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Experimental Surgery - UEPA, Belem-PA, Brazil

  • Pages
    7
  • From page
    949
  • To page
    955
  • Abstract
    Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. Results: Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.
  • Keywords
    Ischemia , Reperfusion , Saline Solution , Hypertonic , Liver , Rats
  • Journal title
    Acta Cirurgica Brasileira
  • Serial Year
    2017
  • Full Text URL
    www.scielo.br/j/acb/a/DqyrLYLc73y7Khk8ZdkCZrd/?format=pdf&lang=en
  • Record number

    2617988

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2617988