Author/Authors :
You, Myung-Won Department of Radiology and the Research Institute of Radiology - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Kim, Hyoung Jung Department of Radiology and the Research Institute of Radiology - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Lim, Hyeong-Seok Department of Clinical Pharmacology and Terapeutics - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Kim, So Yeon Department of Radiology and the Research Institute of Radiology - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Byun, Jae Ho Department of Radiology and the Research Institute of Radiology - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Kim, Kyung Won Department of Radiology and the Research Institute of Radiology - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Hwang, Dae Wook Department of Surgery - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea , Lee, Young-Joo Department of Surgery - University of Ulsan College of Medicine - Asan Medical Center - Seoul, Republic of Korea
Abstract :
To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the diference in liver function
in a rat hepatectomy model. Methods. A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following
groups: control group without hepatectomy (n = 16), 70% hepatectomy group (n = 14), and 90% hepatectomy group (n =
26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained.
Pharmacokinetic analysis was performed using a noncompartmental method. Statistical analysis was performed using one-way
analysis of variance and post hoc pairwise group comparisons. Results. Afer excluding 6 rats that died unexpectedly, blood samples
were obtained from 16, 14, and 20 rats in the control group, 70% hepatectomy group, and 90% hepatectomy group. There was a
signifcant increase in area under the concentration-time curve from time zero to the time of the last measurable concentration
between the 70% and 90% hepatectomy group (p < 0.001). The volume of distribution at steady state was signifcantly decreased
between the control and 70% hepatectomy group (p < 0.001). The clearance was signifcantly diferent in all pairwise group
comparisons (p < 0.001). Conclusions. The vascular clearance of Gd-EOB-DTPA can identify the diference in liver function in a
rat hepatectomy model.
