Author/Authors :
Huang, Hongbo Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Li, Ke Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Lv, Gaochao Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Liu, Guiqing Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Zhao, Xueyu Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Liu, Qingzhu Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Wang, Shanshan Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Li, Xi Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Qiu, Ling Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Lin, Jianguo Jiangsu Key Laboratory of Molecular Nuclear Medicine - Jiangsu Institute of Nuclear Medicine - Wuxi, China
Abstract :
Positron emission tomography (PET) imaging is a useful method to evaluate in situ estrogen receptor (ER) status for the early
diagnosis of breast cancer and optimization of the appropriate treatment strategy. The 18F-labeled estradiol derivative has been
successfully used to clinically assess the ER level of breast cancer. In order to simplify the radiosynthesis process, one-step 18F- 19F isotope exchange reaction was employed for the 18F-fuorination of the tracer of [
18F]AmBF3-TEG-ES. The radiotracer was
obtained with the radiochemical yield (RCY) of ∼61% and the radiochemical purity (RCP) of >98% within 40 min. Cell uptake
and blocking assays indicated that the tracer could selectively accumulate in the ER-positive human breast cancer cell lines MCF7 and T47D. In vivo PET imaging on the MCF-7 tumor-bearing mice showed relatively high tumor uptake (1.4∼2.3 %D/g) and
tumor/muscle uptake ratio (4∼6). These results indicated that the tracer is a promising PET imaging agent for ER-positive breast
cancers.
