Author/Authors :
Shi, Ximin Department of Nuclear Medicine - Peking union Medical College Hospital - Chinese Academy of Medical Science and Peking union Medical College - Shuaifuyuan - Dongcheng District - Beijing, China , Li, Nan Building 3-B - Zhongguancun Dong Sheng International Pioneer Park - 1 Yongtaizhuang North Road - Haidian District - Beijing, China , Ding, Haiyan Department of Biomedical Engineering - School of Medicine - Tsinghua University - Beijing, China , Dang, Yonghong Department of Nuclear Medicine - Peking union Medical College Hospital - Chinese Academy of Medical Science and Peking union Medical College - Shuaifuyuan - Dongcheng District - Beijing, China , Hu, Guilan Department of Nuclear Medicine - Peking union Medical College Hospital - Chinese Academy of Medical Science and Peking union Medical College - Shuaifuyuan - Dongcheng District - Beijing, China , Liu, Shuai Department of Biomedical Engineering - School of Medicine - Tsinghua University - Beijing, China , Cui, Jie Building 3-B - Zhongguancun Dong Sheng International Pioneer Park - 1 Yongtaizhuang North Road - Haidian District - Beijing, China , Zhang, Yue Building 3-B - Zhongguancun Dong Sheng International Pioneer Park - 1 Yongtaizhuang North Road - Haidian District - Beijing, China , Li, Fang Department of Nuclear Medicine - Peking union Medical College Hospital - Chinese Academy of Medical Science and Peking union Medical College - Shuaifuyuan - Dongcheng District - Beijing, China , Zhang, Hui Department of Biomedical Engineering - School of Medicine - Tsinghua University - Beijing, China , Huo, Li Department of Nuclear Medicine - Peking union Medical College Hospital - Chinese Academy of Medical Science and Peking union Medical College - Shuaifuyuan - Dongcheng District - Beijing, China
Abstract :
Kinetic modeling of dynamic 11C-acetate PET imaging provides quantitative information for myocardium assessment.
The quality and quantitation of PET images are known to be dependent on PET reconstruction methods. Tis study aims to
investigate the impacts of reconstruction algorithms on the quantitative analysis of dynamic 11C-acetate cardiac PET imaging.
Methods. Suspected alcoholic cardiomyopathy patients (N = 24) underwent 11C-acetate dynamic PET imaging after low dose
CT scan. PET images were reconstructed using four algorithms: fltered backprojection (FBP), ordered subsets expectation
maximization (OSEM), OSEM with time-of-fight (TOF), and OSEM with both time-of-fight and point-spread-function (TPSF).
Standardized uptake values (SUVs) at diferent time points were compared among images reconstructed using the four algorithms.
Time-activity curves (TACs) in myocardium and blood pools of ventricles were generated from the dynamic image series. Kinetic
parameters k1 and k2 were derived using a 1-tissue-compartment model for kinetic modeling of cardiac flow from 11C-acetate
PET images. Results. Significant image quality improvement was found in the images reconstructed using iterative OSEM-type
algorithms (OSME, TOF, and TPSF) compared with FBP. However, no statistical diferences in SUVs were observed among the
four reconstruction methods at the selected time points. Kinetic parameters k1 and k2 also exhibited no statistical diference
among the four reconstruction algorithms in terms of mean value and standard deviation. However, for the correlation analysis,
OSEM reconstruction presented relatively higher residual in correlation with FBP reconstruction compared with TOF and TPSF
reconstruction, and TOF and TPSF reconstruction were highly correlated with each other. Conclusion. All the tested reconstruction
algorithms performed similarly for quantitative analysis of 11C-acetate cardiac PET imaging. TOF and TPSF yielded highly
consistent kinetic parameter results with superior image quality compared with FBP. OSEM was relatively less reliable. Both TOF
and TPSF were recommended for cardiac 11C-acetate kinetic analysis.
Keywords :
PET , 11C , TAC , Dynamic
