Title of article
Crystal structure of glycidamide: the mutagenic and genotoxic metabolite of acrylamide
Author/Authors
Hemgesberg, Melanie N. Food Chemistry and Toxicology - University of Kaiserslautern, Germany , Bonck, Thorsten Theoretical Chemistry - University of Kaiserslautern, Germany , Merz,Karl-Heinz Food Chemistry and Toxicology - University of Kaiserslautern, Germany , Sun, Yu Inorganic Chemistry - University of Kaiserslautern, Germany , Schrenk, Dieter Food Chemistry and Toxicology - University of Kaiserslautern, Germany
Pages
8
From page
1
To page
8
Abstract
The title compound, glycidamide (systematic name: oxirane-2-carboxamide), C3H5NO2, is the mutagenic and genotoxic metabolite of acrylamide, a food contaminant and industrial chemical that has been classified as being probably carcinogenic to humans. Synthesized via the reaction of acrylonitrile and hydrogen peroxide, it crystallizes with both enantiomers occurring as two crystallographically independent molecules (A and B) in the asymmetric unit. They have similar conformations with an r.m.s. deviation of 0.0809 Å for molecule B inverted on molecule A. In the crystal, molecules are linked by N—H⋯O hydrogen bonds, which lead to the formation of β-sheet structures enclosing R22(8) and R42(8) loops. The β-sheets are linked by weaker C—H⋯O hydrogen bonds, forming a supramolecular three-dimensional structure.
Keywords
β-sheet , crystal structure , glycidamide , acrylamide , hydrogen bonding , genotoxic metabolite , mutagenic
Journal title
Acta Crystallographica Section E: Crystallographic Communications
Serial Year
2016
Record number
2618561
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