Title of article :
18F-FDG-PET/CT Imaging in Advanced Glottic Cancer: A Tool for Clinical Decision in Comparison with Conventional Imaging
Author/Authors :
Paone, G Department of Nuclear Medicine and PET/CT Centre - Imaging Institute of Southern Switzerland - Bellinzona, Switzerland , Martucci, F Department of Radiotherapy - Oncology Institute of Southern Switzerland - Bellinzona, Switzerland , Espeli, V Department of Medical Oncology - Oncology Institute of Southern Switzerland - Bellinzona, Switzerland , Ceriani, L Department of Nuclear Medicine and PET/CT Centre - Imaging Institute of Southern Switzerland - Bellinzona, Switzerland , Treglia, G Department of Nuclear Medicine and PET/CT Centre - Imaging Institute of Southern Switzerland - Bellinzona, Switzerland , Ruberto, T Department of Nuclear Medicine and PET/CT Centre - Imaging Institute of Southern Switzerland - Bellinzona, Switzerland , Richetti, A Department of Radiotherapy - Oncology Institute of Southern Switzerland - Bellinzona, Switzerland , Piantanida, R Department of Otolaryngology-Head and Neck Surgery - Ospedale Regionale di Lugano - Lugano, Switzerland , Giovanella, L Department of Nuclear Medicine and PET/CT Centre - Imaging Institute of Southern Switzerland - Bellinzona, Switzerland
Abstract :
This study assessed the role of 18F-FDG PET-CT (PET/CT) to detect the cartilage and paraglottic infiltration in advanced glottic
cancer comparing the results with those of conventional imaging (CI) (contrast-enhanced computed tomography and/or
magnetic resonance). In addition, we assessed the prognostic value of quantitative parameters, measured on baseline PET/CT, in
terms of event-free survival (EFS) and overall survival (OS). We retrospectively analyzed 27 patients with glottic squamous cell
carcinoma stage III and IVA, treated in our institute between 2010 and 2016, comparing PET/CT, performed for staging and
radiotherapy planning, and CI findings. Cohen’s K was used to compare concordance between PET/CT and CI. Imaging findings
were correlated with endoscopic evaluation and histological reports (gold standard (GS)). All lesions shown by CI were also
detected by PET/CT imaging, and in 5 cases, a better definition of local infiltration was achieved with PET/CT than CI (5 CT).
Sensitivity, specificity, and accuracy of PET/CT and CT were 95%, 86%, and 93% and 70%, 86%, and 74% for, respectively. MRI
showed sensitivity and specificity of 100%. One false-negative (FN) cases and 1 false-positive (FP) case were observed with PET/
CTwith no dif¡erence compared to MRI (10 cases). Six FN cases and 1 FP case were observed with CT. Cohen’s K was 0.60 (PET vs.
CI) and 0.80 (PET vs. GS). Patients were followed-up for at least 24 months to calculate EFS and OS. 13 local recurrence and 7
deaths were recorded. Among quantitative PET parameters, baseline MTV was the most powerful predictor of outcome. Our data
suggest a reliable sensitivity and accuracy of PET/CT in the evaluation of local extension, proving a useful method for initial local
staging in addition to the well-established role in lymph-node and distant sites assessment. Furthermore, pretreatment MTV
provides better prognostic information than other PET/CT parameters.
Keywords :
18F-FDG , PET/CT , Tool , GC
Journal title :
Contrast Media and Molecular Imaging
