Author/Authors :
Hernandez-Rivera, Mayra Department of Chemistry MS-60 - Rice University - Houston, USA , Cho, Stephen Y Department of Chemistry MS-60 - Rice University - Houston, USA , Moghaddam, Sakineh E Department of Chemistry MS-60 - Rice University - Houston, USA , Cheong, Benjamin Y Luke’s Health—Baylor St. Luke’s Medical Center - Houston, USA , Cabreira-Hansen, Maria da Graça Luke’s Health—Baylor St. Luke’s Medical Center - Houston, USA , Willerson, James T Luke’s Health—Baylor St. Luke’s Medical Center - Houston, USA , Perin, Emerson C Luke’s Health—Baylor St. Luke’s Medical Center - Houston, USA , Wilson, Lon J Department of Chemistry MS-60 - Rice University - Houston, USA
Abstract :
The poor retention and survival of cells after transplantation to solid tissue represent a major obstacle for the effectiveness of stem
cell-based therapies. The ability to track stem cells in vivo can lead to a better understanding of the biodistribution of transplanted
cells, in addition to improving the analysis of stem cell therapies’ outcomes. Here, we described the use of a carbon nanotubebased contrast agent (CA) for X-ray computed tomography (CT) imaging as an intracellular CA to label bone marrow-derived
mesenchymal stem cells (MSCs). Porcine MSCs were labeled without observed cytotoxicity. The CA consists of a hybrid material
containing ultra-short single-walled carbon nanotubes (20–80 nm in length, US-tubes) and Bi(III) oxo-salicylate clusters which
contain four Bi3+ ions per cluster (Bi4C). The CA is thus abbreviated as Bi4C@US-tubes.
Keywords :
X-Ray , Bismuth/Carbon , Cell , CT
