Author/Authors :
Castiglioni, Isabella Institute of Molecular Bioimaging and Physiology - Milan, Italy , Gallivanone, Francesca Institute of Molecular Bioimaging and Physiology - Milan, Italy , Losio, Claudio San Raffaele Scientfic Institute - Milan, Italy
Abstract :
The area of cancer research is nowadays rapidly evolving
with basic research deepening on the understanding of
molecular mechanisms underlying carcinogenesis and
cancer cells spreading. A body of evidence showed that
human cancers frequently display intratumor phenotypic
heterogeneity whose nature can have profound implications
for both tumor development and therapeutic outcomes.
Genotypic and phenotypic proles have shown increasing
diagnostic and prognostic accuracy of ex vivo biopsy studies
in several cancer diseases.
