Author/Authors :
Kammon, A.M. Al-Fateh University - Faculty of Veterinary Medicine - Department of Poultry and Fish Diseases, Libya , Brar, R.S. Guru Angad Dev Veterinary Animal Sciences University (GADVASU) - College of Veterinary Science - Department of Veterinary Pathology, India , Sodhi, S. Guru Angad Dev Veterinary Animal Sciences University (GADVASU) - College of Veterinary Science - Department of Veterinary Pathology, India , Banga, H.S. Guru Angad Dev Veterinary Animal Sciences University (GADVASU) - College of Veterinary Science - Department of Veterinary Pathology, India , Singh, J. University of Saskatchewan - Western College of Veterinary Medicine - Department of Biomedical Sciences, Canada , Nagra, N.S. Guru Angad Dev Veterinary Animal Sciences University (GADVASU) - College of Veterinary Science - Department of Livestock Production and Management, India
Abstract :
An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar®), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in various organs. Oral administration of 100 mg/kg bw vitamin C partially ameliorated the degenerative changes in kidney and heart. There was insignificant alteration in biochemical and haematological profiles. It is concluded that supplementation of vitamin C reduced the severity of lesions induced by chronic chlorpyrifos toxicity in broilers.
Keywords :
chlorpyrifos , chronic toxicity , clinicopathology , vitamin C , broilers.
