Author/Authors :
sadaba, s.a. universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina , sadaba, s.a. consejo nacional de investigaciones científicas y técnicas (conicet), Argentina , madariaga, g.j. universidad nacional de la plata - facultad de ciencias veterinarias - laboratorio de patología especial veterinaria, Argentina , botto, c.m. corbi universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina , botto, c.m. corbi consejo nacional de investigaciones científicas y técnicas (conicet), Argentina , carino, m.h. universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina , zappa, m.e. universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina , garcía, p. peral universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina , olguín, s.a. universidad nacional de la plata - facultad de ciencias veterinarias - cátedra de métodos complementarios de diagnóstico, Argentina , massone, a. universidad nacional de la plata - facultad de ciencias veterinarias - laboratorio de patología especial veterinaria, Argentina , díaz, s. universidad nacional de la plata - igevet – instituto de genética veterinaria “ing. fernando noel dulout” (unlp-conicet la plata), facultad de ciencias veterinarias, Argentina
Abstract :
Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.
Keywords :
Apoptosis , Arabian horses , Cerebellar abiotrophy , DNA , Purkinje cells
