Author/Authors :
Sanei Sistani, Sharareh Department of Radiology - School Medicine - Zahedan University of Medical Science - Zahedan, Iran , Parooie, Fateme Zabol University of Medical Science - Zabol, Iran , Salarzaei, Morteza Zabol University of Medical Science - Zabol, Iran
Abstract :
The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the
tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT). Method. This meta-analysis
has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases
for articles published from January 1, 2010, to January 1, 2020. By using the Quality Assessment of Diagnostic Accuracy Studies 2
(QUADAS-2) tool, the reviewers assessed the methodological quality scores of the selected studies. We analyzed the sensitivity,
specificity, and accuracy of two diagnostic methods using Meta-DiSc 1.4 and Stata 15. Results. An overall of 15 studies including
1132 patients were included. Sensitivities of PET/CT and MRI were 83.5% and 82.7%, while the corresponding rates for
specificities were 77.8% and 68.4%, respectively. The DOR, PLR, and NLR for MRI were 15.140, 2.92, and 22.6. PET/CT had a DOR
of 25.21. The PLR and NLR for PET/CT were 4.13 and 0.215, respectively. The diagnostic sensitivity and specificity of PET/CTfor
the detection of residual tumor were 86% and 95%, respectively. The corresponding rates for MRI were 73% and 96%, respectively.
The diagnostic sensitivity and specificity of PET/CT for the detection of tumor metastases were 97% and 99%, while the corresponding rates for MRI were 31% and 98%, respectively. Conclusion. 18F-FDG PET/CT seemed to have a better overall diagnostic accuracy in the evaluation of treatment response to chemoradiotherapy in LACC patients. MRI showed a really poor
sensitivity in the detection of metastases, and PET/CT performed significantly better. However, the difference between these two
methods in the detection of residual disease was not significant. More studies are needed to be conducted in order to approve that
18F-FDG PET/CT can be a standard option to assess the treatment response.
Keywords :
18F-FDG , PET/CT , MRI , Tumor
