Author/Authors :
Ohtani, Masahiro Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Suto, Hiroyuki Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Nosaka, Takuto Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Saito, Yasushi Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Ozaki, Yoshihiko Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Hayama, Ryoko Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Naito, Tatsushi Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Takahashi, Kazuto Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Ofuji, Kazuya Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Matsuda, Hidetaka Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Hiramatsu, Katsushi Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Nemoto, Tomoyuki Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan , Shioura, Hiroki Department of Radiology - Faculty of Medical Sciences - University of Fukui - Fukui, Japan , Kimura, Hirohiko Department of Radiology - Faculty of Medical Sciences - University of Fukui - Fukui, Japan , Aoki, Yoshitaka Department of Urology - Faculty of Medical Sciences - University of Fukui - Fukui, Japan , Yokoyama, Osamu Department of Urology - Faculty of Medical Sciences - University of Fukui - Fukui, Japan , Nakamoto, Yasunari Department of Internal Medicine - Faculty of Medical Sciences - University of Fukui - Matsuokashimoaizuki - Eiheiji-cho - Yoshida-gun - Fukui, Japan
Abstract :
Chronic radiation proctopathy (CRP) is late toxicity and associated with morbidity. Aim. To investigate the predictors
of prognosis in patients with CRP after brachytherapy (BT). Methods. One hundred four patients with prostate cancer were treated
with BT or BT followed by external-beam radiotherapy (BT + EBRT). We retrospectively investigated the 5-year incidence of rectal
bleeding and endoscopic findings of CRP using the Vienna Rectoscopy Score (VRS). Twenty patients with VRS ≥ 1 were divided into
the improved VRS group without treatment, unchanged VRS group, and treated group. The parameters associated with alteration
of VRS were analyzed. Results. The incidence of rectal bleeding was 24%. The risk of rectal bleeding was higher in patients treated
with BT + EBRT compared to those treated with BT (𝑝 < 0.0001). The incidence of superficial microulceration was higher in the
improved VRS group than in the unchanged VRS group (𝑝 < 0.05). The incidence of multiple confluent telangiectasia or superficial
ulcers > 1 cm2 was higher in the treated group than in both the improved and unchanged VRS groups (𝑝 < 0.05). Conclusions.
Patients treated with BT + EBRT have a high risk of CRP. Endoscopic findings were useful for prognostic prediction of CRP.
