Author/Authors :
Yaghoubi, Alireza tabriz university of medical sciences - Cardiovascular Research Center - Department of Cardiac Surgery, ايران , Farzam, Saeed guilan university of medical sciences - Department of Cardiology, ايران , Pezeshkian, Masoud tabriz university of medical sciences - Cardiovascular Research Center - Department of Cardiac Surgery, ايران , Golmohammadi, Zahra tabriz university of medical sciences - Cardiovascular Research Center, ايران , Nasiri, Babak tabriz university of medical sciences - Cardiovascular Research Center - Department of Cardiac Surgery, ايران , Azarfarin, Rasoul tabriz university of medical sciences - Cardiovascular Research Center - Department of Anesthesiology and Intensive Care, ايران , Nouri, Mohammad tabriz university of medical sciences - Faculty of Medicine - Department of Clinical Biochemistry, ايران , Safaie, Naser tabriz university of medical sciences - Cardiovascular Research Center - Department of Cardiac Surgery, ايران , Alizadeh Asl, Azin tabriz university of medical sciences - Madani Heart Hospital - Department of Cardiology, ايران
Abstract :
Background: In contrast to conventional on-pump coronary artery bypass grafting (CABG) surgery only mild increase of parameters of oxidative stress is reported during and after off-pump coronary artery bypass grafting. In this study, we attempted to determine the role of off-pump CABG in the myocardial and systemic inflammatory responses. Methods: One hundred patients who underwent elective CABG were divided to three groups: 1) patients underwent off- pump CABG or 2) on-pump CABG surgery with controlled reperfusion and 3) on-pump CABG with noncontrolled reperfusion. We took patients systemic venous blood samples for the measurement of serum level malondialdehyde (MDA), TroponinC (cTnI) and total antioxidant (TAC) and blood level superoxiddismotas (SOD), before and after Ischemia and reperfusion. Results: Mean values of decrease left ventricular ejection fraction (LVEF) after surgery in patients group 3 were higher than patients group2 and also (LVEF) in patients group2were higher than patients group1(P 0.0001).There was significant difference in mean increase in CTnI levels among the three study groups (P 0.0001). The Serum concentration of MDA in the patients group3were significantly higher than other two groups (P 0.0001). The decrease SOD, TAC levels in patients patients group3were more than patients patients group2and than patients group1. Conclusion: We conclude that oxidative stress biomarker were increase in on-pump CABG. Controlled reperfusion on- pump CABG in comparison with noncontroled reperfusion on-pump CABG reduces oxidative stress .We conclude that off- pump CABG technique appears to reduce oxidative stress.
